Jak nola
Artwork by ©️ Jak Nola.
2023.05.01 08:16 shop-inkedone Artwork by ©️ Jak Nola.
2023.02.02 06:07 Gelocreggikraft Jak Nola, New Zealand
2023.01.23 16:01 HHHFreshBotRedux The Weekly [Fresh]ness - week of Sunday, January 15, 2023
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2023.01.20 10:04 Doomedpaladin Xenolinguistics
2022.12.15 00:40 exfishie *Note: this is PUBLIC info* Screenshots of Erik’s likes on Facebook. Does anyone else remember her mentioning that there was infidelity early in their relationship?…. 👀👀
2022.12.10 06:30 angel14072007 Jak_nola
2022.12.10 06:24 angel14072007 ~ Samsara protector; continuous flow of life and death. Beautiful painting by jak_nola
2022.04.06 21:48 DoctorDueDiligence AACR 2022 Selinexor Megathread + AACR Overview + Drug Development
Hi TEAM!
I'm on the mend from an illness, but wanted to post this, and others can post if they would like to as well. I wanted to talk about AACR
Link to Selinexor AACR Abstracts AACR, or American Association for Cancer Research, is a nonprofit that hosts as annual meeting that is really where science meets practitioners. Think of oncology drug development as a continuum. At the beginning you have in vi
tro (think pe
tri dish) treatment of cancer cell lines in a dish, then infecting mice in vivo (alive) and trying different agents on them, then all the way at the end you have large human phase 3 trials, drug approval, and real world evidence. AACR focuses heavily on the beginning part of drug development.
Why is this useful to a biotech investor? Mainly because it allows you to peer down the tunnel so to speak, and see what is happening, what is coming, and what may be useful in the future.
Scientists are truly the unsung heroes of Oncology, they usually don't get the limelight, the pay, or the recognition they deserve, and usually they're sacrificing a lot of mice.
10,000 foot view: Just because a new agent works in a petri dish / mouse model does not mean it will work in a human, not to mention side effects must be taken into account. However if it is an established drug, side effect profile known, and has multiple papers to back up that indication,
it may be a consideration for a research doctor who wants to do an Investigator Initiated Study/Trial (IIS/IIT for short - this is what you will see on
clinicaltrials.gov) which is typically one site, but sometimes a few sites. It is to see if there is a signal in human trials, and is usually a limited number of patients. Again this is one more step towards the final goal of drug development.
Example of Drug Development in regards to AACR IIT Company Sponsored Trial (CST) AACR: Signal Hypothesis of "Nuclear–Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis" which means XPO1 (selinexoeltanexor) targeting may be of benefit in this disease state.
IIT: Dr. Tantravahi at Huntsman in SLC is like, hey this sounds like it's worth checking out, let me see if I write a grant to the company, they will pay me to research this.
They did. He
reported out some data at ASH 2021 and he did an
interview about it.
CST: The company liked the results from the Phase 2 IIT, and decided to do additional studies in this disease state. There are
two trials going on right now in Myelofibrosis -
If anyone is in NOLA for the meeting and needs restaurant reccs beyond Cafe Du Monde, feel free to ask in the comments!
I plan on linking a few of the abstracts, breaking it down, and giving my thoughts.
Godspeed! Dr. DD Link to
Free Newsletter Sign-up (infrequent)
PS Not Financial Advice!
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2021.10.15 21:26 o0hhhnoo0o Jak Nola always gets me with how stunning she is
2021.09.07 20:03 StillbornTartare Artist Jak Nola is a work of art herself
2021.03.31 03:08 JustAnonPerspective Vaccine resources v1
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2020.01.16 18:19 callmearookie Team Review, Guards Dilemma, Ideas (IMO)
I wanted to write something else after this loss against Miami, so I took what I posted yesterday and wrote it better and modified.
I wanna start by analyzing the Marco-Forbes-Lonnie dilemma. What Marco and Forbes do on the court is useless and hurt us and maybe somebody didn't really understood this. I'm not here to say that what I think is correct but I would love to five another view of things.
I mean, they are pretty much the same type of player, they can only shoot 3s and to be real they aren't that good. Forbes can't shoot over other guards, at least starters, or it's rare and also he's really incosistent. One night he can score 20 and then he loses the next game for us. It's not to give him the fault but if one of DW or Lonnie or DJ played more instead of him we would have won and not only this game against Miami, but other ones. So his ineffectiveness might be caused by the fact he is starting, even if I don't know how much better we would be off the bench. Marco...yeah, rarely drains random 3s that help us but he hurts us more than he helps us. Oh, almost forgot, these two guys play zero defense, really, they are like ghosts on the defensive end.
So, what would we do? The first move would be playing DJ and DW way more and start them together. Yeah, cause like this we might solve a lot of current problems. DW showed that, if well served, can drains 3s consistently and also this guy know what defense is. Anyway, DJ and DW are still not 100% confident because of their past injuries so this affect their defense, especially DW, but they still play good Dand maybe together they can "complete themselves". Also from the bench play Patty as always at 1 and Lonnie at 2. Lonnie plays with effort on defence, maybe he's not the best to do it, but he tries and comes out that's good. Forbes and Marco, at this point, are pretty, not at all, useless cause someone else can cover what they do.
So now, that I'm here, I wanna talk about another thing I saw someone disliked: Rudy. Yeah, he bricked yesterday and I'm not even a big fan of him but Pop, imo, plays him wrongly. Rudy is more a SF than a PF so playing him as a 3 might help him being more effective. For example against big guys like Miami tonight might be more difficlut for him to shoot. Anyway I don't really like him too but he, imo, is used wrongly. And pretty much the same thingscan be said about Lyles who should come off the bench and play 4, not 5 where Jak plays from the bench. About him, he has been good for us and I'm good with him coming off the bench, even if he should play more. About DD, I can only say he proved the haters he is a damn star in this league and he is playing like crazy. About LA he has been good for us lately, this game was just difficult being guarded by Bam so I can understand and also he is another one who plays the wrong position sometimes; he is a 4, not a 5. So I quick summary down here.
STARTERS | 2nd String | 3rd String |
Dejounte Murray | Patty Mills | |
Derrick White | Lonnie Walker IV | |
DeMar DeRozan | Rudy Gay | Keldon Johnson |
LaMarcus Aldridge | Trey Lyles | Luka Samanic |
| Jakob Poeltl | |
The players I left out are DeMarre Carroll, Bryn Forbes, Marco Belinelli and sadly Chimezie Metu. I think these are the ones tradable. Analyzing by player you will understand what I mean with *tradable*. DeMarre is pretty obvious. Pop doesn't play him at all. He might be good but he is 33 and maybe some contenders would want him more than what we need. Bryn and Marco I analyze before. Sadly Metu cause might leave us this FA. By trading these guys, we can't get a star in return but I think at most a starter. I'm personally focused on player, Favors. If NOLA understand that at the of January can't get to the playoffs, might sell. Favors would bring us a lot of rebounds and plays good D and he is expiring.
SAS get Derrick Favors and Kenrich Williams/Frank Jackson
POR get DeMarre Carroll and Marco Belinelli
MIN get Kent Bazemore
NOLA get Gorgui Dieng and Bryn Forbes and 3 2nds, one second from each team.
It works but it's kinda tricky and maybe I can't value players from other teams so don't judge me a lot for this. My idea is that we get DF (and a filler) especially for rebounding cause it's one of our lacks. POR get some good role players that are better than Bazemore and could help them reach the PO. MIN get a nice guard cause they need one. NOLA get a center, cause they don't really have one, that proved he can be good we KAT isn't out there. His contract is bad but it's only for one season so maybe, if they really want, they can move him this summer. Also they would get a young guard that can only shoot 3s, if they need him... Also we would have a free spot so we could sign a guy like Jeff Green or CJ Miles that can help us with our run to the PO.
\OBVIOUSLY IF YOU HAVE OTHER TRADES IN MIND, I INVITE YOU TO SUGGEST THEM DOWN HERE\**
Also this draft we have to, no excuses, draft a big. I would love to see us take Vernon Carey Jr.. I can't understand why he is mocked around 20s, but this is good cause he could snag him. Imo, he is a damn beast and he is a low post master so under Timmy might improve even more and his attitude is kinda "Spursy" so watch out.
So that's it. This team needs to be fixed, that's it. We are good.
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2017.09.10 23:39 LH_Premium "Hello" in every Google Translate language
I WOULD NOT TAKE THIS LIST WITH YOU TRAVELING. I JUST USED GOOGLE TRANSLATE.
afrikaans, south africa - Hoe gaan dit met jou?
albanian, albania - Si po ja kalon?
amharic, ethiopia - አንቺ ግን እንዴት ነሽ?
arabic, middle east - كيف هي احوالك؟
armenian, armenia - Ինչպես ես?
azerbaijani, azerbaijan - Necəsən?
bangla, bangladesh - তুমি কেমন আছ?
basque, pyrenees - Nola egiten duzu?
belarusian, belarus - Як твае справы?
bosnian, bosnia and herzegovina - Kako si?
bulgarian, bulgaria - Как си?
burmese, myanmar - sorry, this language is not supported
catalan, catalonia/andorra - Com va?
cebuano, philippines - Giunsa nimo?
chinese simplified, china - 你好吗?
corsican, corsica - Cumu fai?
croatian, croatia - Kako si?
czech, czech republic - Jak se máš?
danish, denmark - Hvordan har du det?
dutch, netherlands - Hoe gaat het?
english, U.S./U.K./Oceania - a little self-explanatory, is it not?
esperanto, global - Kiel vi fartas?
estonian, estonia - Kuidas sul läheb?
filipino, philippines - Paano mo ginagawa?
finnish, finland - Miten menee?
french, france - Comment allez-vous?
galician, spain - Como estás?
georgian, georgia - როგორ ხარ?
german, germany - Wie geht es Ihnen?
greek, greece - Πώς είσαι?
gujarati, india - શુ કરો છો?
haitian creole, haiti - Koman ou ye?
hausa, nigeria - Yaya kake yin?
hawaiian, hawaii - Pehea ʻoe e hana nei?
hebrew, israel - מה שלומך?
hindi, india - आप कैसे हैं?
hmong, china/vietnam - Koj ua dabtsi?
hungarian, hungary - Hogy vagy?
icelandic, iceland - Hvernig hefurðu það?
igbo, nigeria - Kedu ka ị mere?
indonesian, indonesia - Apa kabar?
irish-gaelic, ireland - Conas atá tú?
italian, italy - Come te la passi?
japanese, japan - お元気ですか?
javanese, java - Piye kabarmu?
kannada, india - ನೀವು ಹೇಗೆ ಮಾಡುತ್ತಿದ್ದೀರಿ?
kazakh, kazakhstan - Қалыңыз қалай?
khmer, cambodia - តើអ្នកសុខសប្បាយជាទេ?
korean, korea - 잘 지내?
kurdish, turkey/iraq/iran/armenia/syria - Rewş çawa ye?
kyrgyz, kyrgyzstan - Кандай жүрөсүң?
lao, laos - ເຈົ້າສະບາຍດີບໍ?
latin, rome - Quid agis?
latvian, latvia - Kā tev iet?
lithuanian, lithuania - Kaip tau sekasi?
luxembourgish, luxembourg - Wéi geet et dir?
macedonian, macedonia - Како си?
malagasy, madagascar - Ahoana ny fahasalamana?
malay, malaysia - Bagaimana awak lakukan?
malayalam, india - എങ്ങിനെ ഇരിക്കുന്നു?
maltese, malta - Kif sejjer?
maori, new zealand/cook islands - Pehea koe e mahi ana?
marathi, india - तुम्ही कसे आहात?
mongolia, mongolian - Юу байна да?
nepali, nepal - तपाईलाई कस्तो छ?
norwegian, norway - Hvordan går det?
nyanja, malawi/zambia/mozambique - Zikukuyenderani bwanji?
pashto, afghanistan - څنکه یی؟
persian, persia - حال شما چطور است؟
polish, poland - Jak się masz?
portuguese, portugal - Como vai você?
punjabi, india - ਤੁਸੀਂ ਕਿਵੇਂ ਕਰ ਰਹੇ ਹੋ?
romanian, romania - Ce mai faci?
russian, russia - Как дела?
samoan, samoa - Oa mai oe?
scottish-gaelic, scotland - Ciamar a tha thu?
serbian, serbia - Како си?
shona, zimbabwe/mozambique - Uri kuzviita sei?
sindhi, pakistan - توهان جا ڪهڙا حال آهن؟
sinhala, sri lanka - ඔයාට කොහොම ද?
slovak, slovakia - Ako sa máš?
slovenian, slovenia - Kako si?
somali, somalia - Sidee tahay?
southern sotho, lesotho - U ntse u ea joang?
spanish, mexico/spain - ¿Como estas?
sundanese, java - Kumaha kabar anjeun?
swahili, tanzania/kenya/uganda/DRC - Unafanyaje?
swedish, sweden - Hur mår du?
tajik, tajikistan - Шумо чӣ хел?
tamil, india - நீங்கள் எப்படி செய்கிறீர்கள்?
telugu, india - నువ్వు ఎలా చేస్తున్నావు?
thai, thailand - เป็นอย่างไรบ้าง?
turkish, turkey/cyprus - N'aber?
ukrainian, ukraine - Як справи?
urdu, pakistan - آپ کیسے ہیں؟
uzbek, uzbekistan - Ahvoling yaxshimi?
vietnamese, vietnam - Làm thế nào bạn đang làm gì?
welsh, wales - Sut wyt ti?
western frisian, friesland - Hoe giet it mei dy?
xhosa, south africa - Wenza njani?
yiddish, germany/israel - וויאזוי גייט עס?
yoruba, nigeria - Bawo ni o ṣe n ṣe?
zulu, south africa - Unjani?
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